The correlation study between coronary artery plaque properties and high-sensitivity c-reactive protein in unstable angina pectoris by intravascular ultrasound
REN Jia-yi
HE Gui-xin
QIN Wei-bin
LIU Peng-ye
WU Kai
Abstract：Objective To investigate the correlation between hypersensitive C-reactive protein (hs-CRP) and the features of virtual histological plaque imaging of coronary artery lesions in patients with unstable angina. Methods A retrospective study was performed between January 2015 and December 2016 in patients, who were diagnosed with coronary heart disease at the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine and received coronary arteriography (CAG) and intravascular ultrasound (IVUS). Stable angina (SAP) patients were selected as control group, and unstable angina (UAP) patients as the experimental group. The correlation between morphological characteristics of plaques under intravascular ultrasound and serum hs-CRP levels were analyzed. Results A total of 56 subjects were enrolled in this study, including 34 patients in the UAP group and 22 patients in the SAP group. There was no significant difference in the risk factors and lesions of coronary heart disease between the two groups (P＞0.05). In the comparison of plaque lesions in the two groups, the lipid pool area, plaque lipid ratio, and plaque eccentricity index of the plaque lesions in the UAP group were significantly greater than those in the SAP group (P＜0.05). There was no significant difference in measurement indexes between the UAP group and SAP group in the external elastic membrane area, the smallest chamber diameter, stenosis rate, plaque load, plaque area, plaque fibrous cap thickness, reconstruction index, blood vessel diameter or lumen diameter (P＞0.05). There was significant difference in serum hs-CRP between the two groups (P＜0.01). The lipid pool area and plaque lipid ratio of plaque lesions in UAP patients was positively correlated with serum hs-CRP (r=0.377 and 0.320, P＜0.05). Conclusion The lipid pool area, plaque lipid ratio and plaque eccentricity index of UAP patients are significantly different from those of SAP patients. Serum hs-CRP level of the former is also significantly higher than that of the latter. Plaque instability in UAP patients is closely correlated to serum hs-CRP, suggesting that serum hs-CRP is an important detection index to assess the condition changes of UAP patients.
Keywords：intravascular ultrasoundcoronary arteriographyunstable angina pectorishypersensitive C-reactive protein
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 498-502 )