Correlation between Fibulin-3 and the branchial-ankle pulse wave velocity in patients with essential hypertension and type 2 diabetes mellitus
ZHANG Chi-ming
WANG Zhuo
LI Wen-lei
YU Chan
LIN Zhong-wei
CHEN Ying-yu
Abstract：Objective To investigate the correlation between Fibulin-3 and the branchial-ankle pulse wave velocity (baPWV) in patients with essential hypertension and type 2 diabetes mellitus (T2 DM). Methods A total of 55 patients with essential hypertension and T2 DM (case group), 62 patients with essential hypertension (control group) and 35 healthy individuals (normal group) were included. Serum levels of Fibulin-3, hs-CRP, and AngII were measured by enzyme-linked immunosorbent assay, latex immunoturbidimetry, and radio immunoassay methods, respectively. The baPWV was measured by the automatic pulse wave velocity meter. Results The serum level of Fibulin-3 in the case group was significantly lower than those in the control group and the normal group [ (40.92±21.84) ng/mL vs. (52.61±27.24) ng/mL and (68.00±29.62) ng/mL, P＜0.05]. The levels of hs-CRP, AngII and baPWV in the case group were significantly higher than those in the control group and the normal group [ (5.96±2.93) ng/L vs. (2.63±1.92) ng/L and (1.22±0.71) ng/L; (55.28±4.97) ng/L vs. (50.29±5.59) ng/L and (47.39±3.05) ng/L; (1 870.33±371.16) cm/s vs. (1 706.11±361.68) cm/s and (1 535.34±253.83) cm/s; P＜0.05]. Fibulin-3 was significantly negatively correlated with baPWV (r=-0.420, P=0.029), hs-CRP (r=-0.570, P=0.011) and AngII (r=-0.586, P=0.013). Conclusion The degree of arteriosclerosis is higher in patients with essential hypertension and T2 DM. Fibulin-3 is involved in the process of vascular remodeling and closely related to inflammation. Further study of its mechanism may help to delay the arteriosclerosis process and target organ damage.
Keywords：essential hypertensiontype 2 diabetes mellitusfibulin-3baPWV
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 362-365 )