The effects of low molecular weight heparin on vascular factors of women with recurrent spontaneous abortion
ZHONG Wei-fen
YAN Hong-jin
YANG Li-jun
LI Ping
KUANG Yan-hong
YANG Jie-ping
Abstract：Objective To investigate the expression of thrombospondin-1 (TSP-1), vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in the women with recurrent spontaneous abortion (RSA) during treatment with low molecular weight heparin (LMWH). Methods Thirty-six women with RSA were enrolled from January 2017 to March 2018, and assigned into therapy group. Thirty-one normal pregnant women during the same period were enrolled in control group. Comparison was conducted between the patients from the 2 groups concerning TSP-1, VEGF and Sflt-1. The adverse reactions during the use of LMWH was also observed. Results The sflt-1 at the 6th week of pregnancy in therapy group was significantly higher, but TSP-1 and VEGF were significantly lower than those of control group (P＜0.05). The sFLT-1 in therapy group was not significantly increased with the pregnancy weeks (P＞0.05). The levels of TSP-1 and VEGF in therapy group were significantly increased with the pregnancy weeks (P＜0.05). The levels of TSP-1 and VEGF at the 8th week pregnancy in therapy group were significantly higher than those of at the 6th week (P＜0.05). Among 36 cases treated with LMWH, small ecchymoma were found in 3 cases (8.33％), and only one case of light pain in the location of subcutaneous injection.Conclusion The abnormal expressions of sFLT-1, VEGF and TSP-1 affect RSA. Low-dose LMWH is safe and effective in the therapy of pregnant women with RSA.
Keywords：low-molecular-weight heparin sodiumrecurrent spontaneous abortionVEGF
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 358-361 )