A cross-sectional study of the association between cognitive impairment and serum 25-hydroxyvitamin D level in senior hemodialysis patients

GUO Yi-dan; LUO Yang

doi:10.13820/j.cnki.gdyx.20185575

Abstract：Objective To investigate the correlations between cognitive impairment of senior hemodialysis patients and serum 25-hydroxyviamin D (25-OH-D). Methods A cross-sectional study was performed in 106 hemodialysis patients. The cognitive function was evaluated by Montreal Cognitive Assessment (MoCA), and serum 25-OH-D level was assessed. A multi-logistic regression was performed to access the potential associated risk factor of cognitive impairments. Results The MoCA scores of 69 senior hemodialysis patients (65.1％), who aged from 60 to 86, were less than 26, which was defined as cognitive impairment. The prevalences of mild cognitive impairment in the 3 groups according to different 25-OH-D levels were 75.5％, 57.9％ and 52.6％, respectively; which were significantly increased in vitamin D deficiency groups. Multi-logistic regression analysis showed that age, educational status, anemia, and diabetics were associated with cognitive impairment, with the odd ratios (ORs) of 1.67 (1.13-2.42), 1.17 (1.04-2.34), 1.37 (1.10-2.71) and 2.20 (1.60-3.12), respectively (P＜0.05). Serum 25-OH-D level was independently associated with cognitive impairment (P＜0.05), with the OR (95％CI) of 1.12 (1.01-1.23). Conclusion Cognitive impairment is common in senior hemodialysis patients. It might be associated with anemia, senior age, educational status, hypertension and diabetics. There is also an association between cognitive impairment and serum 25-OH-D level, which might be a potential intervention measure in the future.