The diagnosis and treatment of ALK-positive lung adenocarcinoma with brain metastasis: case report
HE Dong-yun
WANG Feng-nan
DENG Qiu-hua
HUANG Li-yan
YANG Hai-hong
Abstract：Objective To investigate the clinical manifestations and treatment of a case of brain metastases in ALK-positive lung adenocarcinoma caused by KIT/PDGFRA gene amplification. Methods A case of KIT/PDGFRA gene amplification resulted in a brain metastasis of ALK-positive lung adenocarcinoma were reported with literature review. Results The surgical tissue of patients with brain metastases was detected by second-generation gene sequencing(NGS). The results showed that KIT and PDGFRA genes were amplified. Treatment with crizotinib in combination with KIT/PDGFRA tyrosine kinase inhibitor(TKI)has achieved good results. Conclusion The mechanism of brain metastasis in patients with ALK-positive lung adenocarcinoma is unclear. Crizotinib combined with brain radiotherapy or second-generation ALK-TKI therapy may be selected. Biopsy is feasible as intracranial progression.
Keywords：KIT/PDGFRA gene amplificationALK positivebrain metastaseslung adenocarcinoma
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 55-59 )