The early effects of stereotactic radiotherapy on neurocognitive function and activities of daily living in patients with brain metastases
SONG Chang-long
XIE Guo-wei
KANG Jing-bo
WANG Jin-feng
ZHANG Jun
LUO Ze-min
ZHANG Zong-ping
Abstract：Objective To investigate the early effects of stereotactic radiotherapy(SRT)on neurocognitive function(NCF)and activities of daily living(ADL)in patients with brain metastases. Methods Forty-eight patients with brain metastases treated by SRT were divided into two groups, neurological symptoms group and non-neurological symptoms group. Mini Mental State Scale(MMSE)and Activities of daily living scale(ADL)were used to evaluate NCF and ADL. The scores of MMSE and ADL were evaluated 1 week before SRT, at the end of SRT and three months after SRT.The changes of the scores in two groups were analyzed before and after radiotherapy to evaluate the early effects of SRT on NCF and ADL in patients with brain metastases. Results In non-neurological symptoms group, there was no significant decrease in scores of MMSE and ADL after SRT comparing with the scores before SRT. In neurological symptoms group, the scores after SRT was significantly higher than those before SRT(P ＜ 0.05). Conclusion SRT can improve the NCF and ADL in patients with neurological symptoms, but not affect the NCF and ADL in patients without neurological symptoms.
Keywords：brain metastasesstereotactic radiotherapy (SRT)neurocongnitive function (NCF)ability of daily living (ADL)
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 46-49 )