Association between the polymorphism of ATP10D gene and coronary heart disease in the Han ethnical group in Guangdong Province
ZHENG Jia-kun
SHEN Jia
LIN Mei-hua
JIANG Rui-na
ZENG Jing-tang
WANG Kang
LIANG Yan
RAO Shao-qi
Abstract：Objective To investigate the association between the single nucleotide polymorphism (SNP) of ATP10D, rs2351791 and coronary heart disease ( CHD ) in Guangdong Han population.Methods A tagSNP (rs2351791) was picked out from ATP10D gene.Using the TaqMan probe genotyping method , this SNP was genotyped in 664 CHD cases and 657 health controls of Han origin , collected in Guangdong province.Chi－square test and logistic re-gression model were employed for statistical analysis.Results The frequencies of CC, CA and AA in CAD group were 50.2%, 41.4%and 8.4%, respectively; and 48.0%, 43.3%, 8.6%, respectively, in control group.No significant difference was observed in frequency of ATP 10D rs2351791 genotypes between cases and controls (P＞0.05).Allele fre-quencies of A and C were not significantly different between the case group and the control group (OR＝1.05, 95%CI＝0.76－1.33).Furthermore, after adjustment of sex, age, smoking, hypertension and diabetes, rs2351791 was not signif-icantly associated with CHD under different genetic models ( additive, dominant and recessive ).Conclusion Genetic polymorphism of ATP10D rs2351791 is not associated with coronary heart disease in the Han ethnical group in Guangdong Province.
Keywords：ATP10Dsingle nucleotide polymorphismcoronary heart diseasegenetic susceptibility
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1795-1799 )