Effect of gadolinium－DTPA on diffusion tensor MR imaging for the evaluation of the late stage of brain glioma in rats
LI Xiang-ying
JIANG Xi-li
YUAN Yuan
CHEN Jian-qiang
ZHAN Yue-fu
YANG Guang
Abstract：Objective To evaluate the effect of gadolinium －DTPA on diffusion tensor MR imaging for evaluation of the late stage of brain glioma in rats.Methods C6 glioma cells were stereotactically injected into the right caudate nucleus of 35 Wistar rats.About 3 to 4 weeks after implantation , two diffusion tensor imaging scans were performed －one natively, and the second following with a gadolinium contrast agent application.The FA values were obtained by selecting the tumor body, the peritumor tissue and the contralateral brain tissue.The difference in FA values between the corre-sponding parts before and after injection was analyzed by paired t test.Results Thirty－five late C6 gliomas were exam-ined by DTI, statistically significant differences between pre －contrast and post－contrast DTI were shown in the FA val-ues of the tumor area and the peritumor edema area (P＜0.05).FA values of the contralateral brain tissue showed no sta-tistically significant difference between pre －and post－contrast (P＞0.05).Conclusion Six minutes after injection of Gd－DTPA, FA values of tumor and peritumor tissues increased , while FA value of the contralateral brain tissue had no significant change.DTI scan should be completed before the injection of contrast agent.
Keywords：RatGliomaDiffusion tensor imagingFractional anisotropyContrast medium
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1761-1764 )