Hyperglycemia during chemotherapy in elderly Ph-negative acute lymphoblastic leukemia: risk factors and the impacts on prognosis
LI Zhang-kun
ZHENG Rui-nian
LAI Ying-chang
YAO Zhuo-xin
YAO Shu-yi
Abstract：Objective To investigate whether hyperglycemia during chemotherapy influences the prognosis of eld -erly Ph-negative acute lymphoblastic leukemia (ALL), and the incidence and the risk factors of hyperglycemia .Meth-ods The clinical medical records of 68 cases newly diagnosed patients with Ph -negative ALL in the People′s Hospital of Dongguan city from January 2010 to December 2017 were retrospectively analyzed .All patients had no history of diabetes . The induction chemotherapy was performed with a modified Hyper -CVAD regimen.Results The total incidence of hy-perthermia was 45.5%.There was no significant difference in complete remission rate between hyperglycemia group and non-hyperglycemia group; but the incidence of secondary fungal infection was increased and the overall survival period was shortened in hyperglycemia group .Multivariate analysis showed that , high risk dangerous stratification , initial LDH level ≥2 times the upper limit and extramedullary violations were high risk factors for hyperthermia .Conclusion The in-cidence of hyperglycemia during chemotherapy in elderly patients with ALL is relatively high , especially in patients with high-risk, initial high LDH and extramedullary violations , suggesting a poor prognosis .The monitoring and regulation of hyperglycemia should be part of the overall treatment of leukemia.
Keywords：acute lymphoblastic leukemiaelderlysecondary hyperglycemiaprognosisrisk factors
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1492-1496 )