Role of serum immunoglobulin light chains in monitoring and predicting prognosis of chronic kidney disease
TAN Li-ming
LONG Ting-ting
GUAN Xiao-lin
WU Si-fan
ZHENG Wei
FU Hui-ying
WANG Qiao-hua
MENG Yi-mei
WU Yang
ZENG Ting-ting
TIAN Yong-jian
YU Jian-lin
CHEN Juan-juan
LI Hua
CAO Li-ping
XU hui
Abstract：Objective To evaluate the role of serum immunoglobulin light chains in monitoring and predicting prognosis of chronic kidney disease .Methods Totally 1512 chronic kidney patients (CKD) were assigned into 3 groups, chronic renal insufficiency group (Group CRI, n＝743), chronic renal failure group (Group CKF, n＝155), and ne-phritic syndrome group (Group NS, n＝614).Meanwhile, 73 cases of urinary tract infection group (Group UTI) and 50 healthy participants for physical examination (Group Control) were also selected.Immune scatter turbidity was applied to detect the levels of urinary free light chains and serum light chains .Results The levels of serum free κand λlight chains in Group NS was significantly lower than those in Group CKD and CKF (P＜0.01).The levels of urine free κand λlight chains in Group CRI, CKF, NS and UTI were significantly higher than those in Group Control (P＜0.01).Compared with Group UTI (0) and Control (0), the proportions of the patients with urinary κand λfree light chains double positive were significantly higher in Group CRI (51.9%), CKF (65.6%) and NS (67.9%) (P＜0.05).And they were also significantly higher in Group NC and CKF than that in Group CRI (P＜0.05).Conclusion Detection of the level of uri-nary free light chains has a profound impact in the aspect of diagnosing chronic kidney disease , evaluating patient′s condi-tion and the degree of renal corpuscle and tubular injuries.
Keywords：chronic kidney diseaseserum κλlight chainsurinary κ
Publication Date：2018-05-12
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1483-1487 )