Clinical significance of tumor marker Cyfra211 in the diagnosis and treatment of primary squamous carcinoma of cervix
JIANG Yan-hong
CHEN Guang-yi
SHENG Jia-he
XU Qing-xia
Abstract：Objective To investigate the clinical significance of tumor marker Cyfra 211 in the diagnosis and treatment of primary squamous carcinoma of cervix (SCC).Methods Clinical data of 99 cases of untreated primary SCC patients in the Department Gynecologic oncology of Henan Cancer Hospital from January 2014 to December 2016 were ret-rospectively reviewed, whose average age was 55 years with range from 25 to 76 years.Non-squamous carcinoma of cer-vix (non-SCC) control group and normal control group were set up .The levels of serum Cyfra211 before and after treat-ment were determined by electrochemical method .Mann-Whitney U test was used to analyze the difference of Cyfra 211 levels among each group.The efficacy of serum Cyfra211 in diagnosis of SCC was analyzed by ROC curve .The correla-tions between Cyfra211 before and after treatment and FIGO staging , the degree of cell differentiation and 3 years of follow-up of SCC were analyzed by Spearman correlation analysis .Results The Cyfra211 level of ESCC group was significant-ly higher than those of non -SCC group and normal control group (Mann-Whitney U value: 1810.00 and 752.50, P＜0.05).When the Cyfra211 value was 4.04ng/ml, the sensitivity (80.80%) and specificity (78.40%) were ideal.The level of Cyfra211 before treatment was positively correlated with the stage of FIGO and the degree of cell differentiation in patients with SCC (R: 0.248 and 0.287, P＜0.05).The rate of Cyfra211 change was only positively correlated with the degree of cell differentiation before and after treatment (R: 0.237, P＜0.05).The Cyfra211 levels before and after the treatment or the rate of Cyfra211 change had no correlation with SCC 3 years follow-up results (R: 0.110, 0.027 and 0. 125, P＞0.05).Conclusion The serum Cyfra211 level can be used as a standard for differential diagnosis of SCC . There is a positive correlation between the level of Cyfra 211 and the stage of FIGO and the degree of cell differentiation in patients with SCC before and after treatment , and the rate of Cyfra211 change has positive correlation with the degree of differentiation of cancer cells.
Keywords：squamous cell carcinoma of cervixtumor markercytokeratin 19 fragment antigen
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1478-1482 )