Effect of ELeng Capsule on expression of VEGF, bFGF and PDGF in rats with endometriosis
XU Zheng
LIANG Xue-fang
ZHENG Wei-lin
LIU Jia-qian
LUO Mei-cheng
ZHAO Hui-jun
CAO Li-xing
Abstract：Objective To study the treatment effect of ELeng Capsule in rat models of endometriosis , to investi-gate its effect on vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and platelet derived growth factor (PDGF), and to discuss its mechanism of angiogenesis inhibition .Methods Female SD rats were select-ed.Endometriosis model was constructed with auto grafting method .The endometriosis rats were randomly divided into model group, ELeng Capsule high -dose group, medium-dose group and low-dose group.After treatment for 4 weeks, the lesion tissues were collected .The levels of VEGF, bFGF and PDGF were detected by immunohistochemistry and en-zyme linked immunosorbent assay (ELISA).Results Eleng Capsule significantly inhibited the endometriosis of rats in drug groups (P＜0.05), and alleviated pathological change in lesions .Compared with the normal group , the expression of VEGF in serum and the levels of VEGF , bFGF and PDGF in endometriosis tissues of rats in model group was signifi-cantly higher (P＜0.01), but there was no significant difference in the expression of bFGF and PDGF between model group and normal group (P＞0.05).Compared with model group , the levels of VEGF, bFGF and PDGF in blood serum and endometriosis tissues of rats in drug groups were significantly lower than model group ( P＜0.05).Conclusion ELeng Capsule inhibits the growth of endometriosis tissues in rats .ELeng Capsule significantly suppresses endometriosis angiogenesis in rat model and it may have a closed relation with the inhibition of angiogenesis.
Keywords：ELeng Capsuleendometriosisagiogenesisvascular endothelial growth factorbasic fibroblast growth factorplatelet derived growth factor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1435-1440 )