Effect of different doses of epinephrine on the hemodynamics during fiberoptic bronchoscopy under general anes-thesia
YI Ming-liang
YIN Hong
ZHAO Cong
WANG Jian-sheng
HOU Zheng-you
WANG Jian-ping
Abstract：Objective To investigate the effect of different doses of epinephrine on the hemodynamics during fi -beroptic bronchoscopy under general anesthesia .Methods Eighty patients (ASA Ⅰ-Ⅱ) undergoing fiberoptic bronchos-copy were randomly divided into 4 groups (n＝20 each), Group C, Group E1, Group E2 and Group E3.Anesthesia was performed with continuous intravenous drip of remifentanil and propofol monitored by bispectral index (BIS) to maintain BIS at 40-60 in all groups.The patients in Group E1, Group E2 and Group E3 were all treated with a continuous intrave-nous drip of epinephrine at 0.015 μg/(kg·min), 0.02 μg/(kg·min) or 0.025 μg/(kg·min), respectively, at the induction of general anesthesia .Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and cardiac output (CO) were recorded at baseline (T0), 1 min (T1) and 2 min (T2) after the induction of anesthesia , at the time of laryngeal mask placement (T3), when the tip of the bronchoscope reached glottis (T4) and carina (T5), at end of the examination (T6) and at awake (T7).The duration of anesthesia , duration of bronchoscopy and emergence time were recorded.The arterial lactate also tested at T0 and 7.Results Compared with those at T0, SBP, DBP and CO were significantly reduced at T1, 2, 3, 4, 5 and 6 in Group C (P＜0.05).Compared with those at T0, SBP and DBP were significantly reduced at T1, 2, 3, 4, 5 and 6 in Group E1; while CO was significantly reduced at T 1, 2 and 3 (P＜0.05).Compared with those at T0, HR and CO were significantly increased at T1, 2, 3, 4, 5 and 6 in both Group E2 and E3 (P＜0.05).Compared with Group C, SBP, DBP and CO were significantly increased at T 1, 2, 3, 4, 5 and 6 in both Group E2 and E3, while HR was significantly increased at T1, 2, 3, 4, 5 and 6 in Group E3 (P＜0.05).The arte-rial lactate was significantly lower in Group E2 than that in Group C at T0 (P＜0.05).Conclusion Continuous intrave- nous drip of epinephrine at 0.02 μg/(kg·min) or 0.025 μg/(kg·min) at the induction of general anesthesia may ef-fectively alleviate the hypotension induced by remifentanil and propofol , while the influence of heart rate of epinephrine at 0.02 μg/(kg·min) is relatively smaller.
Keywords：epinephrinebronchoscopyanesthesiageneralhemodynamics
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1315-1318 )