The hemodynamic effect of combined treatment of ephedrine and dexmedetomidine on the old patients
FENG Kang-ping
SUN Yu-ping
NAN Xi-lin
ZHANG Xin-jian
Abstract：Objective To investigate the hemodynamic effect of combined treatment of ephedrine and dexmedeto -midine on old patients.Methods Sixty patients (ASAⅡ-Ⅲ), scheduled for total knee replacement were randomly di-vided into 3 groups (n＝20 in each group ), control group (Group C), low doses ephedrine plus dexmedetomidine (Group E1) and high doses ephedrine plus dexmedetomidine (Group E2).Dexmedetomidine (200 μg) was given in Group C, while ephedrine of 15 mg and 30 mg were plus in Group E1 and E2.MAP and HR were recorded at baseline (T0), 5 min (T1), 10 min (T2), 15 min (T3), 20 min (T4) and 30 min (T5) after administration.The lowest value of HR and MBP, and how long it took to reach the lowest value in each group were recorded thirty minutes after giving medicine.The difference and percentage of the base and minimum values were calculated .Results Compared with Group E2, the HR and MBP were gradually reduced from T 2 in Group C and E1, and it was more prominent in Group C than Group E1.The HR and MBP reached the lowest value in the Group C faster than Group E 1.The HR and MBP showed no significant change in Group E2 since T0.Conclusion Ephedrine can prevent Dex -induced bradycardia and hypotension, delay the decline in heart rate and blood pressure , and reduce the rate of decline .
Keywords：dexmedetomidineephedrineblood pressureheart rateold patients
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1294-1296 )