Efficacy of trimetazidine in patients with stable angina pectoris with contrast induced nephropathy

HUANG Ying-ying; YE Zi-liang; SU Qiang

doi:10.3969/j.issn.1001-9448.2018.08.025

Abstract：Objective To observe the efficacy of trimetazidine in patients with stable angina pectoris with contrast induced nephropathy (CIN).Methods Totally 99 patients with stable angina pectoris who underwent coronary angiogra-phy in our hospital from April 2015 to April 2017 were selected and divided into control group (n＝53) and trimetazidine group (n＝46) according to whether they were treated with trimetazidine .The control group was given conventional treat-ment of coronary heart disease , and the trimetazidine group was given with trimetazidine on the basis of the control group (trimetazidine was given from 3 days before operation , to 7 days after operation , 3 times a day).The serum creatinine (Scr), cystatin C and glomerular filtration rate (eGRF) were recorded at 24 h, 48 h and 72 h.Results The incidence of CIN (4.35%) in trimetazidine group was significantly lower than that in control group (16.98%) ( χ2＝3.979, P＝0.046).The Scr, cystatin C and eGRF in the trimetazidine group were significantly better than those in the control group after 24 h (OR＝1.78, 95%CI: 1.54～1.89; OR＝0.32, 95%CI: 0.28～0.53; OR＝1.53,95%CI: 1.26～1.79, respectively).The Scr, Cystatin C and eGRF in the trimetazidine group were significantly better than those in the control group after 48 h (OR＝1.72, 95%CI: 1.43～2.06; OR＝0.28, 95%CI: 0.24～0.41; OR＝1.58, 95%CI: 1.22～1.74, respectively).The Scr, Cystatin C and eGRF in the trimetazidine group were significantly better than those in the control group after 72 h (OR＝1.78, 95%CI: 1.43～2.06; OR＝0.26, 95%CI: 0.22～0.35; OR＝1.50; 95%CI:1.24～1.63, respectively).The Scr, Cystatin C and eGRF of trimetazidine group were significantly better than those of control group after grouping analysis by gender (all P＜0.05).Conclusion Trimetazidine can significantly reduce the in-cidence of CIN in patients with stable angina pectoris .