Correlation between circulating tumor cells and Ki-67 in non-small cell lung cancer
ZHENG Qiao-rui
TAN Xiang
WANG Yong-yong
DAI Lei
LIANG Guan-biao
CHEN Ming-wu
Abstract：Objective To investigate the correlation between circulating tumor cell (CTCs) and Ki-67 expres-sion or clinicopathological parameters in non -small cell lung cancer (NSCLC).Methods The CTCs in blood was sepa-rated by CanPatrolTMCTC enrichment technique .The expression of Ki -67 in surgical specimens was analyzed by immu-nohistochemistry.The correlation between CTCs and Ki -67 was analyzed.Results The positive rate of CTCs in 75 pa-tients with NSCLC was 92%.The positive rate of interstitial CTCs were 30.1%, 42.9%, 50.0%and 66.7%in StageⅠ(n＝26), Stage Ⅱ(n＝21), Stage Ⅲ(n＝22) and Stage Ⅳ(n＝6) NSCLC, respectively.At Stage Ⅲ and Ⅳ, the positive rate of CTCs was significantly higher than that at Stage ⅠandⅡ(χ2＝4.265, P＝0.039).The positive rate of CTCs was significantly different between those with lymph node metastasis and without lymph node metastasis ( χ2＝4.904, P＝0.027).The positive rate of interstitial CTCs was increased with the progression of NSCLC .There was no sig-nificant difference in Ki -67 index or interstitial CTCs positive rate among genders , ages, pathologic types or differentia-tions (P＞0.05).The positive rate of interstitial CTCs in Ki -67 high expression group was 55.1%(27/49), which was significantly higher than that in Ki -67 low expression group (30.8%, 8/26) (χ2＝4.041, P＝0.044).Conclusion In CTCs, the positive rate of interstitial CTCs increases with progression of NSCLC , and the Ki-67 expression is closely correlated to the positive rate of interstitial CTCs .
Keywords：non-small cell lung cancercirculating tumor cellsKi-67
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1154-1158 )