The risk factors of distant metastases within 1 year after surgery in patients with limited stage small cell lung cancer
ZHAO Cheng
HAO Ji-qing
Abstract：Objective To investigate the risk factors of distant metastases within 1 year after surgery in patients with limited stage small cell lung cancer (LSSLC). Methods Between May 2014 and May 2016, clinical data of 272 LSSLC patients underwent surgery were retrospectively analyzed. According to occurrence of distant metastases within 1 year after surgery, the patients were divided into distant metastases group and non - distant metastases group. General clinical characteristics and related risk factors were compared between two groups. Multivariable logistic regression analysis was performed to predict the risk of distant metastases within 1 year after surgery. Results In 272 cases, 42 cases (15.4％) had distant metastases and 230 cases (84.6％) were with no distant metastases. Common distant metastasis organ were listed as follows, brain (9/42, 21.4％), bone (6/42, 14.3％) and liver (5/42, 11.9％). The metastasis lymph node was on supraclavicular lymph node (5/42, 11.9％) - No statistically significant differences were observed between two groups in maximum tumor dimension, lymph nodes resection, prophylactic cranial irradiation or treatment modalities. Distant metastases group had significantly higher percentages of lymph nodes metastasis of multiple stations, clinical stage of TNM≥Ⅱ b, pure chemotherapy and chemotherapy cycles＜4 when compared to non - distant metastases group, but lower proportion of preventive irradiation in the lymphatic drainage area (all P＜0.05). Multivariable logistic regression analysis showed that lymph nodes metastasis of multiple stations (OR = 2.058, 95％ CI 1.465 - 4.637), clinical stage of TNM ≥ Ⅱ b (OR=4.247, 95％ CI 2.134 - 7.482), pure chemotherapy (OR = 3.372, 95％ CI 2.258 - 6.479) and preventive irradiation in the lymphatic drainage area (OR = 1.658, 95％ CI 0.852 - 3.246) were the independent risk factors of distant metastases within 1 year after surgery. Conclusion Evaluation of regional lymph node metastasis and clinical stage, and standard therapy of postoperative adjuvant chemoradiation can reduced the incidence of distant metastases within 1 year after surgery in LSSLC.
Keywords：limited stage small cell lung cancerdistant metastasesregional lymph node metastasisclinical stagepostoperative adjuvant chemoradiation
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 857-860,864 )