Clinical significance of serum cystatin C in neonates with hyperbilirubinemia
WANG Bei-bei
CHEN Yan-hua
XU Feng-ling
Abstract：Objective To analyze the clinical significance of serum cystatin C in neonates with hyperbilirubinemia. Methods A total of 95 neonates with hyperbilirubinemia were enrolled in the Department of Neonatology from October 2016 to May 2017. They were divided into mild, moderate and severe groups according to serum bilirubin levels. In the same period, 34 healthy neonates without hyperbilirubinemia from our department were enrolled as controls. The blood samples in hyperbilirubinemia group were collected on the first day of admission and the 7 th day after treatment, while they were collected on the first day of admission in control group. The levels of serum bilirubin, cystatin C, creatinine and urea nitrogen in neonates were measured and compared. Results The levels of serum Cys C and bilirubin in the mild, moderate and severe groups were significantly higher than those in the control group on the first day of admission (P＜0.05). There was a significantly positive correlation between serum Cys C level and serum bilirubin level (r2=0.596, P＜0.05). There was no significant difference in serum creatinine level or urea nitrogen level among the four groups (P＞0.05). The levels of serum bilirubin and Cys C after treatment in mild, moderate and severe groups were significantly lower than those before treatment (P＜0.05). The serum levels of serum bilirubin and Cys C were slightly higher than those in the control group (P＞0.05), and the levels of serum bilirubin and Cys C were significantly higher in the mild and moderate group compared with the control group (P＜0.05). Conclusion Hyperbilirubinemia can induce neonatal renal injury, and the degree of renal injury is positively correlated with the level of bilirubin. The serum Cys C level in neonates with hyperbilirubinemia is helpful for early detection of renal function damage, thus to guide clinical treatment.
Keywords：neonatalhyperbilirubinemiacystatin C
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 853-856 )