Association Between Gene Polymorphism of Interleukin Receptor-1 Related Kinase-M 22148 A/G and ANCA associated Small Vasculitis in Guangxi Han Population
LI Hui-jia
XUE Chao
LI Wei
HUANG Li
HUANG Bei
LI Xue
Abstract：Objective To investigate the association between the gene polymorphism of interleukin receptor-1 related kinase-M (IRAKM) 22148 A/G and ANCA-associated vasculitis (AAV). Methods The IRAKM + 22148-A/G polymorphism in 121 AAV patients and 216 controls was analyzed by PCR-RFLP. Clinical and pathologic data of the AAV patients with different genotype were also compared. Results The genotypic frequency of IRAKM + 22148 in the AAV patients was 20. 7％ for AA, 28. 1％ for GG, and 51. 2％ for AG, whereas the corresponding percentage in the controls was 23. 6％ for AA, 28. 6％ for GG, and 47. 8％ for AG. The allele frequencies of IRAK-M + 22148 was 46. 3％ for A and 53. 7％ for G in the AAV patients, as 47. 7％ for A and 55. 3％ for G in the controls. No significant difference was found in either genotype distribution or allele frequencies between the AAV patients and the controls (P ＞ 0. 05). Significant increase in cholesterol was found in AA genotype than the other two genotypes (P ＜ 0. 05). No significant difference was found in clinical manifestation, AI and CI among AA, GG and AG genotypes in AAV patients. Conclusion In AAV patients, IRAKM + 22148-A/G gene polymorphism may be associated with cholesterol without significant correlation with genetic susceptibility to primary AAV.
Keywords：ANCA associated vasculitisIRAKMsingle nucleotide polymorphism
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 686-690 )