The prognostic value of high sensitivity C-reactive protein to albumin ratio in chronic obstructive pulmonary disease patients with respiratory failure treated by non-invasive ventilation
ZHANG Ting
SHI Fei
FENG Meng-jie
Abstract：Objective To investigate the prognostic value of high sensitivity C-reactive protein ( hs-CRP) to albumin ( Alb) ratio in acute exacerbation of chronic obstructive pulmonary disease ( AECOPD) patients with respiratory failure treated by non-invasive ventilation ( NIV) . Methods Fifty AECOPD patients with respiratory failure were enrolled. They were treated by NIV. The APACHEⅡ scores, arterial blood pH, PO2, PaCO2, hs-CRP, Alb, and therapeutic prognosis were recorded. The pH, PaO2, PaCO2, hs-CRP/Alb, and APACHEⅡ scores were compared between patients with good prognosis and poor prognosis. The relevances of hs-CRP/Alb to other indicators ( eg. pH, PaO2, PaCO2, and APACHEⅡ scores) were analyzed, and the prognostic value of hs-CRP/Alb was assessed by the receiver operating characteristics curve. Results The poor-prognosis group had significantly higher values of hs-CRP/Alb and APACHEⅡ scores than the good-prognosis group ( P =0. 000, 0. 005) , while the pH level was significantly lower than that of the good-prognosis group ( P =0. 000) . In the meantime, hs-CRP/Alb was significantly correlated to APACHE Ⅱ and PaCO2 ( r =0. 310, -0. 286; P =0. 028, 0. 044) , while no significant correlation between hs-CRP/Alb and pH( or PO2 ) was found ( r =-0. 236, -0. 006; P =0. 099, 0. 966) . The AUCs of pH, PO2, PaCO2, hs-CRP/Alb, and APACHEⅡ score were 0. 080, 0. 401, 0. 583, 0. 848, and 0. 743, respectively. The cut-off value of hs-CRP/Alb for prognosis of AECOPD patients with respiratory failure was 2. 10, with high sensitivity ( 0. 769) and specificity ( 0. 892) . Conclusion Hs-CRP to Alb ratio can contribute to indicate the effects of NIV for AECOPD with respiratory failure, and plays an important role in the predicting the prognosis.
Keywords：hs-CRP to Alb ratioAECOPDrespiratory failurenon-invasive ventilationprognosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 533-536 )