Combined blood stasis syndrome scores and hs-CRP in evaluation of AS plague characteristics in patients with coronary heart diseases

PENG Chun-li; LIANG Dong-hui; HUANG Zeng-yan; LIU Yong-yuan; HUANG Man-ping; ZHANG Hui-jie; JIANG Yu-ning

doi:10.3969/j.issn.1001-9448.2018.01.039

Abstract：Objective To elvaluate the value of the combination of blood stasis syndrome scores and serum of high-sensitivity C-reactive protein(hs-CRP)in evaluation of atherosclerosis(AS)plaques characteristics for patients with coronary heart diseases(CHD).Methods Ninety-six patients with CHD was enrolled,among whom 53 patients were diagnosed as acute coronary syndromes(ACS)and the other 43 patients were diagnosed as stable angina pectoris (SAP).Base on coronary computed tomographic angiography(CCTA), all patients were divided into non -calcified plaque group(37 cases),mixed plaque group(31 cases)and calcified plaque group(28 cases).In each group,general clinical data,blood stasis syndrome scores,serum levels of hs-CRP,as well as blood biochemical report were recorded. Results The hs-CRP level and blood stasis syndrome scores were significantly higher in non -calcified plaque group than those in mixed plaque group and calcified plaque group(P<0.05).Moreover,hs-CRP and blood stasis syndrome scores in mixed plaque group were significantly higher than in calcified plaque group(P<0.05).In non -calcified plaque group and mixed plaque group, the hs-CRP level and blood stasis syndrome scores were significantly positively correlated(r=0.680,P<0.001;r=0.577,P=0.001).Non-calcified plaque and mixed plaque were the major types in the ACS patients,while calcified plaque was the major plaque type in the SAP patients(P<0.05).The blood stasis syndrome scores and hs -CRP level were significantly higher in patients with ACS than those in patients with SAP(P<0.05).Conclusion The level of hs-CRP and blood stasis syndrome scores are positively correlated in non -calcified plaque group and mixed plaque group,and associated with AS plaques characteristics.It might be useful in the evaluation of plaque stability in CHD patients by combining hs -CRP and blood stasis syndrome scores.