Genotyping and Polymorphism of HIV-1 related CCR5Δ32 allele in Three Ethnic Groups in Guizhou
GUO Xue-hong
HE Yan
ZHANG Xiu-xiu
WANG Chan-juan
ZHANG Ting
GUAN Zhi-zhong
Abstract：Objective To investigate the allelic polymorphism of CCR5Δ32 in three ethnic groups in Guizhou. Methods The study population contained 120 samples,of which consisted of 27 Miao people,70 BuYi people and 23 Shui people.Polymerase chain reaction was applied for amplifying target gene fragment,as DNA sequencing was used to verify the accuracy of PCR products.Results The frequency of the mutant CCR5Δ32 allele was 0.Neither the heterozy-gous CCR5-w t/Δ32 mutant nor homozygous were identified in the three ethnic groups.Conclusion The frequency of the mutant CCR5Δ32 allele is very low in the three ethnic groups in Guizhou.
Keywords：CCR5 Δ32 geneGuizhou provinceethnic groups
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 88-91 )