The Influence of Dexmedetomidine at different doses on analgesic effect and early rehabilitation for patients re-ceived Cesarean section with postoperative anesthesia using dezocine combined with flurbiprofen
LUO Hui-lian
XIANG Jun
HUANG Hui-bin
LUO De-xing
Abstract：Objective To investigate the influence of dexmedetomidine at different doses on analgesic effect and early rehabilitation in patients received Cesarean section with postoperative self -control anesthesia using dezocine com-bined with flurbiprofen.Methods A total of 120 patients(ASAⅠ-Ⅱ)received caesarean section with spinal anesthe-sia were selected and randomly assigned into 4 groups(Group DF,D1,D2 and D3).The PCIA formulation in Group DF was dezocine of 25 mg combined with flurbiprofen of 150 mg and diluted into100 mL solution.The loading dose(LD)in Group was 5 mL.The LDs in Group D1,D2 and D3 were 5 mL combined with Dex of 0.3,0.4 and 0.5 μg/kg,respec-tively.A randomized double-blind control study was conducted.The spinal anesthesia plane was at T6.The LCP mode was used:LD plus continuous infusion dose(CI)of 2 mL plus single dose(Bolus)of 2 mL for 24 hours.VAS scores for resting uterine contraction pain,VAS scores for dynamic pain and Ramsay sedation score were recorded 0 h,2 h,4 h,6 h,8 h,12 h and 24 h after operation.The maternal PCIA dosage,the pressing times of PCIA pump(P1),the actual ef-fective number(P2),the possible side effects,the postoperative aerofluxus time(H),the analgesic effect and the com-prehensive comfort were recorded.Results The total amounts of dezocine and flurbiprofen in Group D 2 and D3 were sig-nificantly less than those in Group DF and D1(P<0.05).The VAS scores of resting contraction pain and dynamic pain in Group D2 and D3 significantly lower than Group DF 4-24 h after operation(P<0.05), and significantly lower than Group D1 4-12 h after operation(P<0.05).Furthermore, the pressing times of PCIA(P1)and the actual effective number(P2)were also significantly lower than Group DF and D 1 6-24 h after operation(P<0.05).The Ramsay score in Group D3 was significantly increased 2-24 h after operation, and the incidences of hypotension and bradycardia in Group D3 were significantly higher than those in Group D 1,D2 and DF(P<0.05).The incidences of nausea,vomiting and chill were significantly lower in all Group D 1,D2 and D3 than those in Group DF(P<0.05).The moderate dose of Dex leaded to the most comfortable situation after operation.There was no significant difference in postoperative aerofluxus time among the 4 groups(P>0.05).Conclusion Dex can enhance the intravenous analgesia effect of dezocine combined with flurbiprofen after cesarean section,reduce the side effect.The suggested LD and CI doses of Dex were 0.4 μg/kg.
Keywords：cesarean sectiondexmedetomidindezocineflurbiprofen esterself-controlled intravenousanalgesia
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 21-26 )