Effect of pretreatment of Dezocine combined with dexamethasone on analgesia and recovery quality for hysteros-copy

XIU Huan-huan; ZHANG Tao; LI Ying-yuan; XU Yi-xin; ZHAO Yue; XU Kang-qing

doi:10.3969/j.issn.1001-9448.2018.01.004

Abstract：Objective To investigate the analgesic and sedative effects of pretreatment of dezocine in combination with dexamethasone in patients with hysteroscopy.Methods A total of 120 patients with selective hysteroscopy(ASA I-II,aged 29-50 years)were randomly assigned to 3 groups.All patients were given with intravenous propofol by 3 mg/kg · min in the induction of anesthesia.Group A additionally received an intravenous injection of dezocine(0.1 mg/kg)and dexamethasone(10 mg)15 min before operation.Group B was further given with dezocine(0.1 mg/kg).Group C re-ceived intravenous saline as placebo.The time for falling asleep,the operation time,the recovery time(from the end of surgery to opening eyes upon callings),the time of shaking hands under instructions,the total amounts of propofol and re-spiratory inhibition(SpO2<93%or apnea>15 s),and postoperative adverse reaction(e.g.nausea and vomiting)were recorded.Postoperative uterine contraction pain and visual simulation score(VAS)were also evaluated.Results There was no significant difference in the time for falling asleep or the operation time among the three groups(P<0.05).The dosage of propofol and the incidence of respiratory inhibition were significantly lower in Group B than Group C(P <0.05).The recovery time and directional force recovery were significantly shorter in Group B than Group C(P<0.05). The VAS scores 2 and 4 hours after operation in Group B were significantly less than Group C(P<0.05).The VAS scores 8,12 and 24 hours after operation and the incidences of nausea and vomiting in Group A were significantly lower than Group B(P<0.05).Conclusion The combined application of dezocine and dexamethasone before hysteroscopic surgery can effectively relieve postoperative pain,shorten recovery time, reduce adverse reactions, and improve compre-hensive satisfaction.