The expression of FOXF1 protein in gastric carcinoma and its clinical significance
HUANG Yong
LUO Hui
HUANG Li-jun
OU Guang-sheng
YE Xiao-long
WEI Hong-bo
Abstract：Objective To detect the expression of FOXF 1 protein in gastric cancer and to investigate the correla-tion between its expression and the clinical data or prognosis of gastric cancer patients .Methods The expression of FOXF1 protein in 160 gastric cancer patients and the adjacent normal tissues were predicted by Oncomine microarray data -base.The expression of FOXF1 protein was detected by western blot .The patients were divided into high expression group and low expression group according to the median value of FOXF 1 expression .The clinical data of two groups were com-pared.Kaplan-Meier methods were used to analysis the correlation between FOXF 1 protein and survival.Results On-comine database and Western blot experiments showed that the expression of FOXF 1 protein in gastric cancer was signifi-cantly lower than that in normal tissues (P<0.05).The expression of FOXF1 protein was closely correlated with tumor size, differentiation and tumor staging (P<0.05).Survival analysis showed that the survival rate of low expression group was significantly lower than that of high expression group (P<0.05).Conclusion FOXF1 protein is involved in the de-velopment and progression of gastric cancer , and may be helpful in evaluating the prognosis .
Keywords：FOXF1 proteingastric cancerprognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3800-3802 )