The prognosis and predictable factors analysis of atypical meningiomas in 38 patients
LAI Ming-yao
LI Juan
ZHOU Jiang-fen
SHAN Chang-guo
HONG Wei-ping
ZHEN Jun-jie
LING Xue-bing
WANG Li-chao
CAI Lin-bo
Abstract：Objective To assess the prognosis and potential predictable factors for patients with atypical meningi -omas ( AMs) .Methods A total of 38 patients with AMs were retrospective analyzed .All the tumors were underwent surgical resection and were pathologically confirmed .Fourteen of them were males with a median age of 53.5 years (range, 31-72 years).And 21 cases were convex meningiomas, 5 were basal skull meningiomas.Simpson grade Ⅰ,Ⅱ,Ⅲ, andⅣresection were achieved in 15, 9, 6, and 8 cases, respectively.Three-dimensional conformal radiation therapy was applied in 12 cases postoperatively, with a median Dt of 54Gy (50-60Gy).Results The median follow-up time was 24.5 months (range, 16~108 months).Six patients relapsed and 2 died at the last follow-up.The median progression-free survival (PFS) was 66 months, 5 -year PFS`and 5 -year overall survival (OS) were 53.3% and 80.0%, respectively.In univariate analysis, sex (P=0.023), age (P=0.034) and Simpson grade (P=0.028) were significantly correlated with PFS .Conclusion Surgical resection remains the main method to treat AMs .Female, younger age and Simpson I resection were associated with favorable prognosis .However , postoperative adjuvant radiotherapy did not improve PFS .The conclusions of the present study warranted further research to confirm .
Keywords：atypical meningiomaefficacyprognosisprogression-free survival time
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3758-3761 )