The level of periostin in meningiomas and its clinical significance
CAO Yong-fu
LIU Yi
WANG Chao-hu
KUANG Huan
OUYANG Hui
Abstract：Objective The expression and role of periostin in meningiomas remains unknown .Methods The level of periostin and Ki -67 index were evaluated in 175 convexity meningiomas with immunohistochemical staining .The association of the periostin lever and Ki -67 with patient features were also evaluated .Results The expression of Ki -67 was significantly positively correlated with the WHO grade (r=0.673, P<0.001).Weak staining of periostin was ob-served in 116 (66.3%) cases.The expression of periostin was also positively correlated with the WHO grade (r=0.742, P<0.001).Moreover, there was a positive correlation between the expression of Ki -67 expression and periostin (r=0.513, P<0.001).Finally, both Ki-67 expression and periostin were statistically correlated with tumor recurrence and the duration of PFS (P<0.001).Conclusion Periostin was mainly expressed in the stroma of meningiomas .Both peri-ostin and Ki-67 may behave as a maker characterizing the invasion of meningiomas .Drugs targeting periostin deserves further study .
Keywords：meningiomasperiostinKi-67WHO gradeprognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 3738-3743 )