Neoadjuvant chemotherapy effect and influencing factors on Luminal B breast cancer
ZHANG Wei
LAI Mi-lin
YANG Shi-hong
REN Li-ping
Abstract：Objective To investigate the effect of neoadjuvant chemotherapy ( NAC) and the influencing factors on pCR of Luminal B breast cancer of different subtypes , and to provide references for clinical intervention and prognosis evaluation .Methods In the retrospective study , the clinical materials of 148 Luminal B breast cancer patients with NAC were collected from November 2010 to July 2016.According to the expression of human epidermal growth factor receptor 2 (HER2), they were divided into HER2 negative and HER2 positive subtypes.They were also divided into pCR and non -pCR groups.The chi-square test and logistic regression were applied for analysis .Results Among the 148 patients, HER2 negative subtype (n=93) and HER2 positive subtype (n=55) significantly differed in treatment regimens, treat-ment cycles and pCR rate ( P<0.05 ); there were 14 patients in pCR group ( 5 of HER2 negative subtype , and 9 of HER2 positive subtype), and 104 in non-pCR group.The pCR was significantly affected by ER status , HER2 status and Ki67 index (P<0.05).Conclusion The response to NAC of Luminal B breast cancer HER 2 positive subtype is better than that of HER2 negative.With the effective treatment, NAC cycles can be prolonged to increase likelihood of pCR . ER negative or low expression, HER2 positive and high expression of Ki67 have some predictive values on the effect of NAC.
Keywords：Luminal B breast cancerneoadjuvant chemotherapyeffectinfluencing factors
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 3426-3429,3432 )