3-O-C12 -HSL induces the expression of CD1d via PPARγ in Mo-DCs.
ZHANG Yun-yan
LONG Bao-jun
LI You-qiang
CUI Ying-qiu
MAO Zhe
ZHANG Dong-jie
Abstract：Objective To investigate the effects of 3-O-C12 -HSL on the CD1d in monocyte derived dendritic cells (Mo-DCs) via PPARγ.Methods CD14 +monocytes were collected by immune magnetic bead , and induced to Mo-DCs by monocyte colony stimulating factor and recombinant human interleukin 4.The Mo-DCs were estimated by 3-O-C12 -HSL and (or) GW9662.The CD1d expression in Mo-DCs was detected by flow cytometry .Results We demonstrate that CD1d molecules expressions in Mo -DCs existed significant difference between GW 9662 group and 3-O-C12 -HSL group (P<0.05).Conclusion 3-O-C12 -HSL promotes the expression of CD1d on the surface of Mo-DCs via PPARγ.
Keywords：N-3-oxododecanoy 1-L-homoserine lactonemonocytes derived -dendritic cellsperoxisome pro1iferater-activated receptor γCD1d
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3389-3392 )