Correlation analysis between treatment reactivity on steroid resistant asthma and expression of actin depolymerization factor
LIANG Yong-feng
Abstract：Objective To investigate the correlation between treatment reactivity on steroid resistant asthma (SRA) and expression of actin depolymerization factor (ADF).Methods Thirty-four asthma cases,whose FEV1％ were lower than 75％.Among them,10 cases were SRA and the other 24 cases were steroid-sensitive asthma.The ACQ5 scores,lung function,and symptom scores at day and night were recorded.Induced sputum,peripheral eosinophil count percentage,peripheral neutrophil count percentage and peripheral blood ADF were also measured before treatment.All cases were given with sufficient treatment of prednisolone for 2 weeks.Lung function and ADF expression were assessed again after treatment.Results Before treatment,no significantly difference was observed in ACQ score,symptom scores at day and night,EOS％,B-NEU％,or B-EOS％ between SRA and SSA groups (P ＞ 0.05);while S-NEU％ in SRA group was significantly higher than SSA group (P ＜ 0.05).Neither significant difference in FEV1％ or PEF％ was observed between SRA and SSA groups at baseline (P ＞ 0.05).Significant improvements in FEV1％ and PEF％ were only observed in SSA group after treatment (P ＜ 0.05).The ADF expression in SAR group was significantly higher than SSA group before treatment (P ＜ 0.05),but no significant difference was observed after treatment (P ＜0.05),as it was significantly reduced in SSA group after treatment (P ＜ 0.05).The ADF expression level showed no significant correlation with B-EOS％,B-NEU％,or S-EOS％ before treatment (r =0.27,0.09 and-0.23,P =0.20,0.68 and 0.31).The ADF expression level of peripheral blood was negatively correlated with FEV1％ and positively correlated with S-NEU％ and PEF％ prior treatment (r =-0.40,0.41 and 0.39,P =0.03,0.02 and 0.04).Conclusion The ADF expression level is correlate with treatment reactivity of RSA,and it could be the predictive factor to the treatment reactivity of GC.
Keywords：steroid resistant asthmaactin depolymerization factoreosinophilsneutrophilslung function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 3112-3115,3119 )