Effects of PFOS and PFOA exposure on asthma outcomes and the balance of type 1 and type 2 cytokine in children: a case-control study
YANG Jie-wen
LEE Yong-ling
DONG Guang-hui
Abstract：Objective To assess the associations of serum polyfluoroalkyl substances (PFAAs) concentrations with asthma and key Th2 cytokines in children.Methods A total of 231 asthmatic children and 225 non-asthmatic controls were recruited in the Genetic and Biomarker study for Childhood Asthma.Serum concentrations of two PFAAs and levels of interferon (IFN)-γ,interleukin (IL)-12,IL-4 and IL-5 were measured.Results The significantly higher serum PFAAs were observed in asthmas children than healthy controls.Adjusted odds ratios suggested that PFAAs exposure significantly increased the risk of asthma.PFAAs were positively associated with serum Th2 cytokines and negatively associated with Th1 cytokines among asthmatics.Conclusion Increased serum PFAAs levels may promote Th cell dysregulation and alter the availability of key Th1 and Th2 cytokines,effects that could ultimately contribute to development of pulmonary allergic diseases.
Keywords：perfluorooctanesulfonatetype 1 cytokinetype 2 cytokine
Publication Date：2017-01-01