Correlation Research between Klotho Gene Polymorphisms with Coronary Heart Diseases and Longevity in Hain-an
CHEN Xiao-ping
NING Chao-xue
DENG Jue-lin
ZHAO Ya-li
ZHU Qiao
ZENG Qing
YAO Yao
XUE Qiao
LUAN Fu-xin
Abstract：Objective To investigate the correlation of Klotho gene polymorphisms with coronary heart diseases and longevity in Hainan .Methods Totally 50 cases of longevity were randomly selected from household survey of cente-narians , and 50 patients with coronary heart diseases in 301 hospital of hainan branch institute were selected as experimen-tal group, and 50 healthy people who received physical examination in physical examination center were selected as control group.The sex, age, body mass index (BMI) and blood pressure, blood sugar, blood lipids and other biochemical indi-cators were recorded.ASP-PCR was used to detect G -395A, C1818T, F352V and C370S sites of Klotho gene.Results The C1818T site of Klotho gene was T homozygous in all 3 groups.The F352V site was F homozygous, and the C370S site was C homozygous in both coronary heart disease group and health control group .There was no significant difference a-mong coronary heart disease group , longevity group and control group regarding genotype and allele frequency in G -395A site of Klotho gene (P>0.05).Conclusion There is no correlation among polymorphism of G -395A, C1818T, F352V and C370S of Klotho gene, coronary heart disease and longevity in Hainan Province .
Keywords：klotho genesingle nucleotide polymorphismscoronary artery diseaselongevity
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 3001-3004,3010 )