The early diagnostic utility of hematopoietic cytokines for cervical cancer
DENG Kai-xian
ZHENG Yu-hua
LIU Xiao-chun
WANG Hong
HU Lu-qin
CHEN Yong-lian
WANG Yu-ling
HUANG Xiao-bin
LI Lin-xi
Abstract：Objective To investigate the plasma levels of hematopoietic growth factors ( HGFs) in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), thus to evaluate its application in early diagnosis of cervical cancer.Methods The plasma levels of HGFs ( SCF, GM-CSF, G-CSF and M-CSF) were determined by immu-noenzyme assay (ELISA), and SCC-Ag by chemiluminescent microparticle immunoassay .Results Significantly higher GM-CSF, G-CSF and M -CSF were observed in patients with cervical cancer and CIN than healthy controls ( P<0.05).Significant higher GM -CSF and M-CSF were observed in patients with cervical cancer than those in patient with CIN (P<0.05).The diagnostic specificities GM -CSF, G-CSF, M-CSF and SCC-Ag were high for cervical cancer . The diagnostic sensitivity and the positive predictive value , and negative predictive value of M -CSF were higher than an-tigen SCCAg.Conclusion Further study of HGFs suggests new biomarker for cervical cancer .M-CSF can applied as a biomarker for early diagnosis of cervical cancer and CIN .
Keywords：Cervical cancercervical intraepithelial neoplasiasquamous cell carcinoma antigenHematopoietic growth factor
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2958-2960 )