Correlation between STAT3 and primary ANCA associated vasculitis.

WANG Min-wen; XUE Chao; LIAO Yun-hua; LI Wei; HUANG Li; PENG Qian; LAI Yan-fei.

Abstract：Objective To investigate the correlation between STAT3 polymorphisms in rs2293152 and rs744166 gene and primary ANCA associated vasculitis (AAV) in Guangxi Chinese Han participants.Methods The genotypes of 98 patients with AAV (case group) were initially identified by PCR-RFLP and 213 healthy Chinese Han participants with matched age and gender enrolled in control group.After that, case-control study, clinical and pathologic analysis were conducted.Results The frequency distributions of STAT3 rs2293152 genotype GG, GC and CC in AAV patients were 31.6%, 45.9% and 22.4%, respectively;and were 37.6%, 51.6% and 10.8%, respectively, in controls.The frequencies of allele G and C in the AAV patients were 54.5% and 45.4%, respectively;and were 63.4% and 36.6%, respectively, in controls.The frequencies of CC genotype and C allele were significantly higher in case group than those in control group (P<0.05).It was found that the significant difference in the arthralgia prevalence among GG, GC and CC genotypes, and it was more common in the CC genotype;and so was CRP level.No significant difference was found in the STAT3 rs744188 of neither genotype distribution nor allele frequencies between the patients and the controls (P>0.05).There were significant differences in the incidences of hemoptysis and hematuria among TT, TC and CC genotypes in case group.The incidences of hemoptysis in TT genotype was higher than those in TC and CC, as the incidence of hematuria in TC genotype was higher than those in TT and CC genotypes.The pathological score AI and CI in TC genotype were significantly higher than those in TT and CC genotypes.Conclusion The polymorphism of STAT3 rs2293152 gene in Chinese Han population may be correlated to the genetic susceptibility of AAV.Meanwhile, the frequency distribution of CC genotype and C allele may be correlated to the incidence of arthralgia and the level of CRP in AAV patients.The polymorphism of STAT3 rs744166 gene in AAV patients may be related to the incidences of hemoptysis, hematuria and pathological grade AI and CI.