The effects of Mac-1 deficiency on tumor growth and lipid metabolism in ApcMin/+ mice.
ZHANG Qian-qian
YE Zhi-jin
LI Jiang-chao
WANG Li-jing
Abstract：Objective To investigate the influence of Mac-1 deficiency on tumor growth and lipid metabolism of spontaneous intestinal adenoma.Methods The ApcMin/+ mice and Mac-1 knock-out (Mac-1-/-) mice were expanded.The ApcMin/+ mice were mated with Mac-1-/-mice.The DNA was extracted and genotyped by PCR assay.The tumor number and volume were assessed, and the serum total cholesterol (TC) and triglyceride (TG) were detected.Results The Mac-1 deficiency mice with spontaneous intestinal adenoma were obtained.The tumor number and volume in small intestine were reduced.The serum TG and TC were both reduced by about 40%.Conclusion Mac-1 gene deletion could significantly suppress intestinal adenoma growth, that may correlate with lipid metabolism.
Keywords：Mac-1tumor growthlipid metabolism
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2425-2427 )