The protective effects of Honokiol on myocardial ischemia-reperfusion injury in rats
YI Quan
TAN Fang-hui
CHEN Wei-dong
LI Wei-da
ZHANG Gui-ping
ZHANG Gen-shui
Abstract：Objective To investigate the protective effects of honokiol on myocardial ischemia-reperfusion (I/R) injury in rats.Methods SD rats were assigned into CTL group, I/R model group and HON group.The hemodynamics data, ECG and the serum creatine kinase (CK) were measured.Adult rat cardiomyocytes were isolated with Langendorff perfuse system.Myocardial cell calcium transient was detected with IonOptix fluorescence spectrum detect system.Results Compared with CTL group, LVSP, +dp/dtmax and-dp/dtmax were significantly lower while LVEDP significantly higher in I/R groups (P<0.05).Compared with I/R group, LVSP, +dp/dtmax and-dp/dtmax were significantly higher while LVEDP significantly lower in HON group (P<0.05).Compared with CTL group, the incidence of arrhythmias and activity of CK were significantly higher in I/R group (P<0.05).Compared with I/R group, the incidence of arrhythmias and activity of CK were reduced (P<0.05).Meanwhile, during the first 3 minutes of reperfusion, the onset time of arrhythmia was significantly prolonged (P<0.05), the duration and frequency of arrhythmia were reduced (P<0.05) in HON group.HON reduced myocardial cell calcium transient amplitude.Conclusion HON could improve the cardiac function in myocardial I/R and reduced early reperfusion arrhythmia.This mechanism may be related to the reduction in intracellular Ca2+ and calcium overload in myocardial I/R.
Keywords：myocardial ischemia reperfusionhonokiolhemodynamicsarrhythmiacalcium transient
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2276-2279 )