The correlation between 5-HTTLPR and the susceptibility to chemotherapy-related fatigue in colorectal cancer
LUO Min-rui
WEI Yi-sheng
SU Fang
LIANG Zhi-hua
ZHOU Ya-guang
HONG Chu-yuan
Abstract：Objective To analyze the correlation between serotonin transporter promoter polymorphism (5-HTTLPR) and the susceptibility to chemotherapy-related fatigue in colorectal cancer.Methods The data of 5-HTTLPR genotypes and clinical data of 121 patients with colorectal cancer were retrospectively analyzed.The peripheral blood and clinicopathological data were collected.The correlations between 5-HTTLPR genotype and clinical pathological factors were analyzed by chi-square test.Unconditional logistic regression model was used to analyze the association between 5-HTTLPR variant and colorectal cancer chemotherapy-related fatigue.Results Chi-square test showed that chemotherapy-related fatigue was associated with 5-HTTLPR genotype (P=0.025).Unconditional logistic regression model showed that patients with genotype SS had a significantly higher risk of moderate to severe chemotherapy-related fatigue (OR=8.225, 95% CI 1.694~39.927, P=0.009) than genotype LL.Conclusion The genotype SS of 5-HTTLPR variant is an independent risk factor for moderate to severe chemotherapy-related fatigue in colorectal cancer.
Keywords：colorectal cancer5-HTTLPRchemotherapy-related fatiguesusceptibility
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1981-1984 )