The significance of serum anti-SLA level in patients with HBV-related acute-on-chronic liver failure
ZHANG Hui
XIAO Lei
XU Min
MA Shi-wu
Abstract：Objective To evaluate the significance of serum anti-SLA level in patients with HBV-related acute-on-chronic liver failure (H-A).Methods A total of 26 patients with H-A (H-A group), 16 patients with chronic hepatitis B (CHB group), 17 patients with liver cirrhosis (LC group) and 14 healthy controls were enrolled (HC group).The serum level of anti-SLA was detected by enzyme linked immunosorbent assay.Results The optical density value level of anti-SLA in patients with HBV infection was significantly higher than that of HC group (P<0.001).Moreover, the level of anti-SLA in H-A group was significantly higher than those in CHB group (P<0.001) and LC group (P<0.001).The level of anti-SLA was positively correlated with ALT (r=0.260, P=0.046) and TBIL (r=0.646, P<0.001), but not correlated with HBV-DNA (r=-0.069, P=0.598) in patients with HBV infection.In H-A group, the level of anti-SLA was positively correlated with total bile acid (r=0.478, P=0.024), but not correlated with prothrombin activity (PTA), ALT, AST, DBIL or TBIL.Conclusion It is suggested that the difference of anti-SLA expression among the patients with HBV infection could be assessed using this method, and the high level of anti-SLA in H-A patients might be correlated with the progression and prognosis of acute-on-chronic liver failure.
Keywords：anti-SLAacute-on-chronic liver failureenzyme linked immunosorbent assayhepatitis B virus
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1977-1980 )