Serum betatrophin in population with simple overweight and obesity
LIN Jiang-hong
CHEN Rong-ping
YI Min
ZENG Hui-xian
ZHANG Su-su
ZHANG Xian
CHEN Hong
Abstract：Objective To investigate the correlation between serum betatrophin concentration and metabolic parameters in overweight and obesity patients.Methods Forty-three patients with overweight or obesity and 42 normal weight control subjects were included.Their clinical data were collected.Serum betatrophin and adiponection (APN) concentrations were measured by ELISA.Results The serum betatrophin concentration of overweight or obese subjects was significantly lower than that of control (P<0.01).Serum betatrophin concentration was significantly positively correlated with high-density lipoprotein cholesterol (HDL-C) and APN, and negatively correlated with fasting plasma insulin (FINS), HOMA-IR, triglycetides(TG), low-density lipoprotein (LDL-C) and uric acid (UA) (all P<0.05).Multiple stepwise regression analysis showed that FINS and APN were independent correlated factors that influenced the level of serum betatrophin (P<0.01).Conclusion Serum betatrophin concentration is significantly reduced in overweight or obese patients, and associated with FINS, lipid metabolism and adiponection, suggesting that it may provide as reference for the treatment of obesity and metabolism syndrome.
Keywords：obesitybetatrophinmetabolic parametersadiponection
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1823-1826 )