Anesthesia effects of chloral hydrate and pentobarbital sodium on postoperative fatigue syndrome in rats
CHEN Hong-yan
PANG Feng-shun
CHEN Jing-bao
XIAN Min-ling
YANG Yan-ting
HU Qiong
QIN You
Abstract：Objective To compare the anesthesia effects of chloral hydrate (10%) and pentobarbital sodium (2%) on postoperative fatigue syndrome (POFS) model in rats.Methods Rat model of POFS were established by with enterectomy with anastomosis method.Twenty four adult male healthy rats were randomly divided into 2 groups, chloral hydrate group and pentobarbital sodium group.The durations of anesthesia induction and anesthesia duration, rat mortality, and success rate of the first dose of anesthesia were recorded.Anal temperature was measured at baseline, and 6 hours, 2 days, 4 days, 6 days and 8 days after operation.Morris water-maze test was carried out 2-7 dyas after operation.Meanwhile, grasping test was applied 1 day, 3 days, 5 days and 7 days after operation.Results There was no significant difference in mortality between the two groups.The induction time and deep anesthesia time in chloral hydrate (P<0.05), in which the rectal temperature was regained significantly faster.The maximum grips were significantly greater on Day 1, 3, 5 and 7 in chloral hydrate group (P<0.05), with significantly shorter escape latency and more platform crossing times (P<0.05).Conclusion Chloral hydrate can provide shorter induction time, satisfied duration, and higher the success rate of the first dose of anesthesia, suitable in constructing the POFS model.
Keywords：postoperative fatigue syndromerat modelchloral hydratepentobarbital sodium
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1805-1808 )