The expression and prognostic value of FOXM1 screened by Array-CGH in ductal carcinoma in situ of breast

WANG Yong-nan; ZHANG An-qin; LI Wen-ping; HE Zhou; LI Hui-bin

Abstract：Objective To investigate the expression and the predictive prognosis value of FOXM1 screened by Array-CGH (array-comparative genomic hybridization,Array-CGH) in ductal carcinoma in situ of breast.Methods A total of 101 paraffin specimens of breast ductal carcinoma and breast invasive ductal carcinoma were collected from January 2007 lo December 2014.The expression of FOXM1 screened by Array-CGH was detected by immunohistochemistry,and the prognosis of breast ductal carcinoma was evaluated.Results The positive rate of FOXM1 protein in breast ductal carcinoma was 59.4％ (60/101),with no significant correlation with age,menopause,tumor size,axillary lymph node status,HR status,or HER-2 status.FOXM1 expression in pure DCIS was significantly lower than ductal carcinoma in situ with microinvasiveness (12.2％ vs.31.7％,P =0.032).The median follow-up was 62 months.Disease-free survival rate of all was 97.0％.There was no significant difference in disease-free survival between FOXM1 negative group and FOXM1-positive group (97.6％ vs.96.7％,P =0.787).Overall survivals were both 100％ in FOXM1 negative and positive groups.There was no significant difference between pure DCIS and DCIS-MI in DFS (98.7％ vs.94.7％,P =0.257).There was no significant difference in DFS between pure DCIS patients and DCIS-MI patients in FOXM1 positive group (97.6％ vs.94.4％,P =0.523).In FOXM1 negative group,DFS in pure DCIS patients was significantly superior to DCIS-MI patients (100％ vs.85.7％,P =0.028).Conclusion The positive expression of FOXM1 in DCIS-MI is higher than pure DCIS,which may play a role in the infiltration process of DCIS.The negative expression of FOXM1 may predict the poorer prognosis of DCIS-MI than the pure DCIS.