The expression and clinical value of serum adropin in PCOS patients
HE Xing-feng
WANG Qing-ru
YAO Hui
FENG Xiao
ZHANG Yong-le
FU Xia-fei
Abstract：Objective To study the expression and clinical value of serum adropin in PCOS patients.Methods We selected 53 females, who were initially diagnosed as PCOS, and 21 healthy females as control group.We analyzed the serum adropin by ELISA and quantified the sex hormones and lipid metabolism indicators.Results The serum adropin in PCOS group was significantly lower than control group (P=0.000).The serum T (P=0.012), LH (P=0.027), FSH (P=0.021), TG (P=0.029), LDL (P=0.016), 0-hour insulin (P=0.04), 1-hour insulin (P=0.002), 2-hour insulin (P=0.001) and HOMA-IR (P=0.016) in PCOS group were significantly higher than those in control group.Adropin had a significantly negative correlation with HOMA-IR (r=-0.382, P=0.005).According to the ROC curve, AUC was 0.791 (95% CI 0.690~0.871), sensitivity was 98.11%, specificity was 63.64% and the cut-off was 3.8ng/ml for adropin in diagnosis of PCOS.Conclusion The expression of serum adropin in PCOS is low, which has a negative correlation with serum insulin and HOMA-IR.Adropin is useful for clinical diagnosis and may become a new diagnostic indicator and therapeutic target for PCOS.
Keywords：adropinpolycystic ovary syndromeglycometabolisminsulin resistance
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1505-1508 )