The establishment of placental vascular cast model and its morphology for monochorionic twin pregnancy with selected growth restrain

CHEN Jie; PAN Shi-lei; HANG Li-lin; WANG Ying; YU Yan-hong; ZHONG Mei

doi:10.3969/j.issn.1001-9448.2017.07.010

Abstract：Objective To establish the placental vascular cast model of monochorionic (MC) twin pregnancy with selected growth restrain,and to investigate the morphological changes of placental vascular and its clinical significance.Methods Twenty specimens were collected from women who delivery in Nanfang hospital of Southern Medical University with MC twin pregnancy,among whom 10 subjects with SIUGR were enrolled as Group A and 10 subjects with normal infants were enrolled as Group B.According to the birth weight,they were further subdivided into Group A1,Group A2,Group B1 and Group B2.The placental vascular cast models were constructed for comparison.Results The age in Group A ranged from 20 to 37,with the mean age of (28.36-± 4.79) years,and gestational week of (35.10 ± 2.69) weeks.The age in Group B ranged from 23 to 38,with mean age of (31.04-±5.13) years,gestational week of (35.32-± 2.66) weeks.In Group A,the share rate of two placenta was over 1.5,which was significantly higher than that in Group B.In Group A,6 cases of abnormal umbilical cord attachment (the racket shape or sail the placenta) were observed;as only 1 case of abnormal umbilical cord attachment was observed in Group B.In Group A,rich vascular anastomosis branches were revealed between the twin fetal placenta.There were significant differences in vascular diameters among veins and arteries.In Group B,the vascular anastomosis branches were significantly less than that in Group A,with significantly less diameter differences among vessels.Conclusion Placental vascular anastomosis,placenta sharing degree and abnormal umbilical cord attachment are proved to affect the growth of MC twin fetus.