The correlation between the levels of plasma Hcy and Cyst-C, and carotid intima-media thickness in patients with H-hypertension complicated with type 2 diabetes
MO Xin-ling
YANG Xi-heng
XIE Ting
ZHANG Jin-hua
Abstract：Objective To investigate the correlation between the levels of plasma homocysteine (Hcy) and Cyst-C,and carotid intima-media thickness in patients with H-hypertension complicated with type 2 diabetes.Methods A total of 120 patients with H-hypertension complicated with type 2 diabetes.The application of color Doppler ultrasography was applied for the assessment of carotid intima-media thickness (cIMT).According to the degree of carotid atherosclerosis,the subjects were divided into 3 groups,normal carotid IMT group (cIMT ＜ 0.9 mm),carotid IMT thickening group (0.9 mm≤cIMT ＜ 1.3 mm) and carotid artery plaque group (cIMT≥1.3 mm).According to the level of blood pressure,the subjects were divided into high blood pressure Level-1 (140-159/90-99 mmHg),high blood pressure Level-2 (160-179/100-109 mmHg),and high blood pressure Level-3 (over 180/110 mmHg).The blood sugar,blood fat,blood urea nitrogen,creatinine,serum Hcy,and serum Cyst-C levels were assessed and analyzed.The correlation between serum Hcy,Cyst-C and cIMT was analyzed.Results (1) according to the thickness of the carotid artery was divided into normal group,the thickening of the group,plaque formation,There was no significant difference in blood sugar,blood fat,urea nitrogen or serum creatinine among the 3 cIMT groups (P ＞ 0.05),though there were significant differences in serum Hcy and Cyst-C among them (P ＜ 0.05).(2) The serum Hcy and Cyst-C in high blood pressure Level-3 group was significantly higher than those of Level-1 and Level-2 groups;and they were also significantly higher in Level-2 group than Level-1 group (all P ＜ 0.05).(3) The cIMT was significantly positively correlated with and Hcy,Cyst-C,HbA1c,systolic pressure and diastolic blood pressure (P ＜ 0.05).And Hcy,Cyst-C,HbA1c,and systolic blood pressure were the independent risk factors for the development of cIMT (P ＜ 0.05).Conclusion The serum levels of Hcy and Cyst-C are closely related to the cIMT,suggesting independent risk factors of cIMT.
Keywords：H-hypertension patientsdiabetic mellitushomocysteinecystain-Ccarotic intima-media thickness
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 855-858 )