Study on the effect of hydrogen rich saline on gout arthritis in rats
ZHAO You
FAN Yan-wei
MA Guang-bin
YAN Dong-xue
Abstract：Objective To investigate the protective effects of hydrogen rich saline on acute gouty arthritis model in rats.Methods Forty rats were randomly divided into four groups,control group,model group,hydrogen rich saline group and colchicine group.In colchicine group,0.3 mg/kg colchicine were given with lavage;10 mL hydrogen rich saline were also given in hydrogen rich saline group continuously for 4 weeks.The control group and the model group were given with the same volume of Twain-saline.Acute gouty arthritis model was established at the last time after pretreatment.The acute gouty arthritis models were established on the last time after intragastric administration,by the method of intraarticular injection of sodium urate.The subject joint circumference,interleukin-1 β (IL-1 β) and tumor necrosis factor-α (TNF-α) were measured before and after model establishment.The joint soft tissues were collected for histopathology examination.Besides,combine the behaviors of rats to evaluate the therapeutic effect.Results Compared to the model group,significant improvement in joint circumference,gait,serum IL-1 β and TNF-α and the inflammatory reaction of subject ankle joint were revealed in colchicine group and hydrogen rich saline group colchicine group.Conclusion Hydrogen rich saline can reduce the inflammatory reaction and also effectively inhibit the gout arthritis in rats.
Keywords：gout arthritishydrogen rich salineinterleukin-1 βtumor necrosis factor-α
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 672-674 )