Effect of genetically modified lactic acid bacteria on reproductive development of female rats
QIAN Qing-zeng
CAO Xiang-ke
LIU Hai-yan
Abstract：Objective To investigate the effect of genetically modified lactic acid bacteria on reproductive development of continuous passage female rats.Methods The male and female SD rats were grouped with equal number in genders (6 male rats and 6 female rats in each group).Subjects at 4 weeks old were intragastric administration with non-transgenic plant lactobacillus and transgenic plant lactobacillus in control group and experiment group,respectively.After 4 weeks of intragastric administration,male and female rats mated.The first generation,second generation and third generation were treated with same intragastric administration for 8 weeks.At different time points,body length,tail length,body weight,anogenital distance,ovarian mass,hormone level were compared between the two groups.Results In first generation,second generation and third generation,there was no significant difference in body length,tail length,body weight,or anogenital distance between control group and experimental group (P ＞ 0.05);neither in primary follicle;secondary follicle,corpus count,estradiol,progesterone,or vaginal opening time (P ＞ 0.05).Conclusion There is no negative effect on reproductive development of genetically modified lactic acid bacteria in rats.
Keywords：genetically modified microorganismmultigengrational experimentreproductive and development
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 662-665 )