The expression of HERC2 in breast cancer and its correlation with pathological parameters:a preliminary study
ZHANG Jian
GAO Ge
ZHAN Yuan
CHENG Bo
Abstract：Objective To investigate the expression of HERC2 in breast cancer tissues.As the same time, to ex-plore the correlation between its expression in invasive ductal carcinoma and the pathological parameters .Methods The expression of HERC2 in normal breast tissue, breast benign lesions, ductal carcinoma in situ and invasive ductal carcino-ma was assessed using immunohistochemical staining .The expression of HERC2 in normal breast tissue and invasive duc-tal carcinoma tissue was measured with Western Blot .Results Immunohistochemistry showed that the positive rates of HERC2 in benign breast lesions , ductal carcinoma in situ and invasive ductal carcinoma were 8% ( 4/50 ) , 32% ( 16/50) and 58%(29/50), respectively, among which the differences were significantly (P<0.01), and the positive rate of HERC2 in normal breast tissue was 4%(2/50).The expression of HERC2 in invasive ductal carcinoma was significantly associates with lymph node metastasis and histological grades ( P<0.05 ) .Western Blot showed that the expression of HERC2 in invasive ductal carcinoma was significantly higher than that in normal breast tissue (P<0.05).Conclusion HECR2 may be related to the development and prognosis of breast cancer .
Keywords：HERC2breast cancerimmunohistochemistryWestern blot
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 531-533,537 )