Correlations among lipoprotein-associated phospholipase A2, myeloperoxidase, C-reactive protein and global registry of acute coronary events risk score in patients with coronary heart disease
Abstract：Objective To investigate the correlations among Lp -PLA2, MPO, C-reactive protein (Hs-CRP) and global registry of acute coronary events risk score ( GRACE) risk score in patients with CHD .Methods A hundred and fifty patients were divided into 3 groups undergoing the coronary angiography , stable myocardial infarction ( SMI ) group (n=28), stable angina pectoris (SAP) group (n=59), and ACS group (n=63).The serum levels of Lp -PLA2 and MPO were detected by enzyme -linked immunosorbent assay (ELISA), the serum level of Hs-CRP was detected by latex immunoturbidimetry , and GRACE risk scores were recorded .The correlations among Lp -PLA2, MPO, Hs-CRP and GRACE risk score were analyzed .Results The serum levels of Lp -PLA2, MPO and Hs-CRP in ACS group were significantly higher than SAP group and SMI group (P<0.05), while there was no significant difference in serum Lp -PLA2, MPO or Hs-CRP between SAP group and SMI group (P>0.05).Lp-PLA2 was significantly correlated with MPO and Hs-CRP in CHD groups (r=0.793, P<0.05; r=0.769, P<0.05); meanwhile, MPO was significantly correlated with Hs-CRP in CHD groups ( r=0.743, P<0.05).There was no significant correlation between Lp -PLA2, MPO or Hs-CRP and GRACE risk score in CHD groups .Conclusion It can further help to assessment the strat-ification of CHD risk and can be more beneficial to predicting and treating the coronary artery disease by jointing test the serum levels of Lp-PLA2, MPO and Hs-CRP or using GRACE risk scores.
Keywords：coronary heart diseaselipoprotein -associated phospholipase A 2myeloperoxidaseC-reactive proteinglobal registry of acute coronary events risk score
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 374-377 )