Berberine inhibit cardiac fibrosis through p38 MAPK pathway
CAI Shao-ai
HU Ming
TANG Xiao-yan
CHEN Mei-ting
LUO Cheng-feng
Abstract：Objective To observe the effects of berberine on cardiac fibrosis , and to investigate the possible mechanism.Methods Cardiac fibroblasts were stimulated by TGF -β1 to establish a cell model of cardiac fibrosis .Car-diac fibroblasts were stimulated with different concentrations of berberine before given with TGF -β1.The cell viability, the expression levels of collagen Ⅲprotein and p38 MAPK protein were tested.Results TGF-β1 at low concentration could increase the viability of cardiac fibroblasts and promote the synthesis of collagen Ⅲ.Berberine showed a inhibitive effect on cardiac fibroblast cell viability in a concentration -dependent manner , which reduced the synthesis of collagenⅢ, and promoted the phosphorylation of p 38 MAPK protein.Conclusion Berberine can inhibit the proliferation of cardi-ac fibroblasts and synthesis of collagen Ⅲvia phosphorylation of p38 MAPK proteins.
Keywords：berberinecardiac fibroblastscell proliferationcollagen Ⅲp38 MAPK
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 337-339 )