Diagnostic value of human growth differentiation factor-15 in patients with acute dyspnea
LU Seng-rong
GUO Shun-qi
CAI Zong-qun
Abstract：Objective To investigate the plasma GDF-15 level in acute dyspnea changes , thus to evaluate the diagnostic value of GDF-15 on dyspnea .Methods A total of 120 emergency patients with acute dyspnea were selected and assigned into simple pulmonary disease group , pulmonary heart disease group , left ventricular dysfunction group , and other causes of dyspnea group according to causes of dyspnea .And 120 healthy physical examination participants were se-lected as normal control group .GDF-15, left ventricular end diastolic diameter (LVEDd), end diastolic interventricular septum (IVS), left ventricular posterior wall ( LVPW), left atrial diameter ( LAD), left ventricular ejection points (LVEF), and E/A value were recorded and compared .Results There were significant differences in LVEDD , LAD, LVEF, LVPW, IVS and E/A ratio between acute dyspnea patients and normal controls (P<0.05).There was no signifi-cant difference in age or sex composition between them (P>0.05).GDF-15 level was significantly higher in acute re-spiratory distress patients than control group ( P<0.05) , so were they in patients with different causes of acute dyspnea (P<0.05).The GDP-15 in left ventricular dysfunction patients was significantly higher than the other 3 groups (P<0.05).And it was significantly higher in patients with other causes of dyspnea than simple pulmonary diseases and pulmo -nary heart disease groups (P<0.05).The area under the ROC curve of GDF -15 (0.876) was the highest in left ven-tricular dysfunction patients .Conclusion GDF-15 can be used as a clinical marker for differential diagnosis of acute dyspnea
Keywords：acute dyspneahuman growth differentiation factor -15diagnostic value
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 217-219 )